The project is a coordinated clinicopathologic investigation of ocular and orbital tumors. The specific objectives of this project are: (1) To improve preoperative methods for the diagnosis of intraocular neoplasms. (2) To expand and maintain an ongoing ocular tumor clinic. (3) Thorough clinicopathologic case documentation on patients with ocular neoplasms. (4) To correlate the behavior in individual tumors in patients with various morphologic and nonmorphologic features of the neoplasm. (5) To test the possibility that retinoblastomas produce nerve growth promoting factor and if this is correct, devise procedures for correlating its production with the presence of this tumor or its metastases. Furthermore, to explore the possibility of treating retinoblastomas with NGF or anti-NGF. (6) To preserve strains of tumor cell clones so that the comparative effect of drugs and other therapeutic agents can be evaluated. The research methods include sophisticated ophthalmologic diagnostic procedures (e.g. fluorescein angiography, light and electron microscopy, as well as tissue and organ cultures).